BPC-157 and TB-500 Blend: Composition and Specifications

Blend composition

The BPC-157 + TB-500 blend is specified as 10 mg/10 mg in one vial. The slash separates the stated quantities of two components; it does not denote a single combined molecule. Inventory records should name both components and retain each amount independently. This simple distinction prevents the blend’s total stated content from being mistaken for the mass of either component or for the molecular weight of a chemical structure.

BPC-157 is specified as a pentadecapeptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Its formula is C62H98N16O22, molecular weight 1419.5 g/mol, and CAS number 137525-51-0. TB-500 is the synthetic short fragment Ac-LKKTETQ, with an acetylated N-terminus, formula C38H68N10O14, and molecular weight 889.0 g/mol. Each component’s identifiers belong to that component, not to the blend as a whole.

Sequence and nomenclature

BPC-157 is a 15-residue peptide, which is why it is described as a pentadecapeptide. The one-letter sequence records the ordered residue composition: glycine, glutamic acid, three proline residues, glycine, lysine, proline, alanine, two aspartic acid residues, alanine, glycine, leucine, and valine. Repeating the sequence in a technical record is valuable because the name alone does not show residue order. Preserve the hyphenation and spelling used in the verified specification.

TB-500’s Ac-LKKTETQ sequence has a different scope. It is a synthetic short fragment name used in research catalogs, whereas thymosin beta-4 is a 43-amino-acid peptide of approximately 4.9 kDa. The blend specification identifies TB-500, not an unspecified full-length peptide. Writing out this distinction helps prevent broad related nomenclature from obscuring the stated component identity.

Formula and mass records

Formula and molecular weight are structure-level identifiers. BPC-157 is listed as C62H98N16O22 and 1419.5 g/mol, while TB-500 is listed as C38H68N10O14 and 889.0 g/mol. These values should be displayed alongside their respective component names. They must not be summed and presented as a molecular weight for the blend, because the vial contains two separately specified materials rather than one molecule with a combined formula.

The CAS number 137525-51-0 is specified for BPC-157. It should not be copied into the TB-500 entry or used as an identifier for the two-component blend. A sound product record distinguishes a component registry number from a product handle, a lot number, and a vial amount. Keeping these identifier types in their own fields supports accurate catalog searches and traceable analytical records.

Manufacturing context

Peptide production commonly uses solid-phase peptide synthesis, or SPPS, in which residues are assembled in a controlled sequence on a solid support. Technical documentation may describe synthesis, purification, and subsequent preparation as distinct stages. For a blend, component identity and component-level analytical records should remain clear before the materials are presented together in the stated vial composition. General process descriptions do not substitute for lot-specific evidence or establish the quality of a particular vial.

Lyophilization is the presentation specified for these materials. The blend is supplied in a sealed glass vial as a lyophilized preparation. A product specification should state the two component amounts without implying that the listed quantities reveal sequence, purity, or any other analytical characteristic. Those matters belong in the applicable lot documentation and should be reviewed as reported, rather than inferred from the blend name.

COA and lot traceability

A lot-matched certificate of analysis connects analytical data to a particular production lot. Review the product name, lot identifier, test methods, reported results, and document date together. HPLC can provide a chromatographic profile, and LC-MS can provide mass-based data for identity assessment. A method label alone is not a finding; the actual result and its stated context matter. The COA should correspond to the same lot number printed on the vial or its associated label.

The site’s Verify a lot page provides a way to check a COA against a lot identifier. Retain the verification reference with receiving records and preserve the distinction between the two components in inventory systems. When product names or abbreviations vary among documents, transcribe each source accurately and reconcile the difference against the lot-specific label and COA. This creates an auditable path from product specification to vial to analytical record.

Component-level review

A blend COA can present combined-product information alongside results for individual constituents, so note the scope of each test before comparing values. A chromatogram attributed to the blend is not automatically a separate purity statement for both ingredients. Where the report provides component-specific findings, preserve the association between each finding and its stated analyte.

For a useful archive, retain the original report file, the date it was retrieved, and any verification reference alongside the vial lot code. Record whether reported peptide content is stated as received or on another basis, and do not recalculate a value without documenting the calculation and its assumptions. These fields make later comparisons easier to audit without turning a reported measurement into a broader claim.

A receiving checklist can also record seal condition, label legibility, and whether the accompanying paperwork names the same two constituents. Note discrepancies as observations with dates and source references; do not infer a result from packaging appearance. This separates receipt inspection from chemical characterization and keeps both records useful.

Storage and shipment

The listed materials are lyophilized in sealed glass vials. Store at 2–8 °C, protect from light, and keep dry. These directions apply to the sealed lyophilized presentation. Record the storage location and lot number so that the vial remains connected to the associated documentation. Any additional handling information should be taken from the applicable product and lot documents, rather than assumed from general catalog terminology.

Shipping is US-only and uses cold-chain handling. At receipt, record the shipment and lot identifiers, note package condition, and associate the vial with its lot-matched COA. For this blend, the central specification is unambiguous when recorded as BPC-157 10 mg and TB-500 10 mg in one vial. Keep the sequence, formula, molecular weight, and CAS number assigned to the correct individual component throughout storage and documentation.